Title : Cellular role of yeast Apn1 apurinic endonuclease/3'-diesterase: repair of oxidative and alkylation DNA damage and control of spontaneous mutation.

Pub. Date : 1991 Sep

PMID : 1715020






1 Functional Relationships(s)
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1 We show here that yeast strains lacking Apn1 (generated by targeted gene disruption or deletion-replacement) are hypersensitive to both oxidative (hydrogen peroxide and t-butylhydroperoxide) and alkylating (methyl- and ethylmethane sulfonate) agents that damage DNA. tert-Butylhydroperoxide DNA-(apurinic or apyrimidinic site) lyase APN1 Saccharomyces cerevisiae S288C