Title : Genetic and pharmacological inhibition of GITR-GITRL interaction reduces chronic lung injury induced by bleomycin instillation.

Pub. Date : 2007 Jan

PMID : 17135359






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 When compared with bleomycin-treated GITR+/+ mice, bleomycin-treated GITR-/- mice exhibited a reduced degree of i) lung infiltration with polymorphonuclear neutrophils (MPO activity); ii) edema formation; iii) histological evidence of lung injury; iv) TNF-alpha and interleukin (IL)-1beta production; v) nitrotyrosine formation; and vi) NF-kappaB activation. Bleomycin interleukin 1 beta Mus musculus