Pub. Date : 2006 Nov 22
PMID : 17122062
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The rewards of nicotine: regulation by tissue plasminogen activator-plasmin system through protease activated receptor-1. | Nicotine | plasminogen activator, tissue | Mus musculus |
| 2 | Here we show that the tissue plasminogen activator (tPA)-plasmin system regulates nicotine-induced reward and dopamine release by activating protease activated receptor-1 (PAR1). | Nicotine | plasminogen activator, tissue | Mus musculus |
| 3 | Here we show that the tissue plasminogen activator (tPA)-plasmin system regulates nicotine-induced reward and dopamine release by activating protease activated receptor-1 (PAR1). | Nicotine | plasminogen activator, tissue | Mus musculus |
| 4 | In vivo microdialysis revealed that microinjection of either tPA or plasmin into the nucleus accumbens (NAc) significantly potentiated whereas plasminogen activator inhibitor-1 reduced the nicotine-induced dopamine release in the NAc in a dose-dependent manner. | Nicotine | plasminogen activator, tissue | Mus musculus |
| 5 | Nicotine-induced dopamine release was markedly diminished in tPA-deficient (tPA-/-) mice, and the defect of dopamine release in tPA-/- mice was restored by microinjection of either exogenous tPA or plasmin into the NAc. | Nicotine | plasminogen activator, tissue | Mus musculus |
| 6 | Nicotine-induced dopamine release was markedly diminished in tPA-deficient (tPA-/-) mice, and the defect of dopamine release in tPA-/- mice was restored by microinjection of either exogenous tPA or plasmin into the NAc. | Nicotine | plasminogen activator, tissue | Mus musculus |
| 7 | Nicotine-induced dopamine release was markedly diminished in tPA-deficient (tPA-/-) mice, and the defect of dopamine release in tPA-/- mice was restored by microinjection of either exogenous tPA or plasmin into the NAc. | Nicotine | plasminogen activator, tissue | Mus musculus |
| 8 | Nicotine-induced dopamine release was markedly diminished in tPA-deficient (tPA-/-) mice, and the defect of dopamine release in tPA-/- mice was restored by microinjection of either exogenous tPA or plasmin into the NAc. | Nicotine | plasminogen activator, tissue | Mus musculus |
| 9 | Nicotine increased tPA protein levels and promoted the release of tPA into the extracellular space in the NAc. | Nicotine | plasminogen activator, tissue | Mus musculus |
| 10 | Nicotine increased tPA protein levels and promoted the release of tPA into the extracellular space in the NAc. | Nicotine | plasminogen activator, tissue | Mus musculus |
| 11 | Targeting the tPA-plasmin-PAR1 system would provide new therapeutic approaches to the treatment of nicotine dependence. | Nicotine | plasminogen activator, tissue | Mus musculus |