Title : Molecular determinants of substrate selectivity of a novel organic cation transporter (PMAT) in the SLC29 family.

Pub. Date : 2007 Feb 2

PMID : 17121826






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Helical wheel analysis of TM5 revealed a distinct amphipathic pattern with Glu(206) and Thr(220) clustered in the center of the hydrophilic face. Glutamic Acid tropomyosin 3 Homo sapiens
2 In summary, our results suggest that Glu(206) functions as a critical charge sensor for cationic substrates and TM5 forms part of the substrate permeation pathway in PMAT. Glutamic Acid tropomyosin 3 Homo sapiens