Title : MEK-ERK-mediated phosphorylation of Mdm2 at Ser-166 in hepatocytes. Mdm2 is activated in response to inhibited Akt signaling.

Pub. Date : 2007 Jan 26

PMID : 17107963






1 Functional Relationships(s)
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1 Further studies revealed that phosphatidylinositol 3-kinase inhibitors LY294002 and wortmannin induced phosphorylated ERK Tyr-204 and pMdm2 Ser-166 phosphorylations in hepatocytes in culture and in rat hepatocytes in vivo. Wortmannin Eph receptor B1 Rattus norvegicus