Title : Treatment with growth hormone receptor antagonist in acromegaly: effect on cardiac structure and performance.

Pub. Date : 2007 Feb

PMID : 17105844






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1 After a baseline evaluation, including measurement of hemodynamic, biochemical, and hormonal parameters, and a standard Doppler echocardiography, treatment with pegvisomant was started at the initial dose of 10 mg/d, increasing by 5 mg/d every 6 wk on the basis of IGF-I levels until normalization or the achievement of a maximal dose of 40 mg/d. pegvisomant insulin like growth factor 1 Homo sapiens