Pub. Date : 2007 Jan 10
PMID : 17098465
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Folate depletion in human lymphocytes up-regulates p53 expression despite marked induction of strand breaks in exons 5-8 of the gene. | Folic Acid | tumor protein p53 | Homo sapiens |
| 2 | Cells grown in 15 nM folate developed significant levels of p53 strand breaks, reflected by reductions in amplifiable DNA from p53 exons 5-8 (approximately 40% loss, P<0.0001) and exons 7-8 (approximately 26% loss, P<0.0001) compared to 30 and 120 nM. | Folic Acid | tumor protein p53 | Homo sapiens |
| 3 | Cells grown in 15 nM folate developed significant levels of p53 strand breaks, reflected by reductions in amplifiable DNA from p53 exons 5-8 (approximately 40% loss, P<0.0001) and exons 7-8 (approximately 26% loss, P<0.0001) compared to 30 and 120 nM. | Folic Acid | tumor protein p53 | Homo sapiens |
| 4 | p53 protein abundance increased with decreasing media folate, as did p21 transcript. | Folic Acid | tumor protein p53 | Homo sapiens |
| 5 | In primary human lymphocytes, folate depletion induces a marked increase in p53 exons 5-8 breaks, but does not reduce steady-state levels of p53 mRNA, protein, or impair downstream signaling. | Folic Acid | tumor protein p53 | Homo sapiens |
| 6 | The induction of p53 strand breaks by folate depletion does not impair p53 expression or action within all human cell lines. | Folic Acid | tumor protein p53 | Homo sapiens |