Title : Strategies for construction of luteinizing hormone beta subunit analogs with carboxyl terminal extensions in non-primate, non-equid mammalian species.

Pub. Date : 2007 Jan 2

PMID : 17092639






3 Functional Relationships(s)
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1 CGbeta genes from the human being and horse have evolved from ancestral luteinizing hormone (LH) beta genes by different pathways that involve deletions that change the reading frames and yield a CTP. Cytidine Triphosphate chorionic gonadotropin subunit beta 3 Homo sapiens
2 In multiple mammalian species, simple frame-shift mutations using either the human or equine CGbeta gene as a model can be used to construct LHbeta analogs with putative CTP domains. Cytidine Triphosphate chorionic gonadotropin subunit beta 3 Homo sapiens
3 Furthermore, DNA sequences from mammalian LHbeta genes can be aligned to maximize similarity with CGbeta genes in order to devise more refined strategies for construction of CTP-bearing LHbeta analogs as exemplified in the bovine case. Cytidine Triphosphate chorionic gonadotropin subunit beta 3 Homo sapiens