Pub. Date : 2007 Jan 15
PMID : 17091492
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | TNF-alpha/IFN-gamma-induced iNOS expression increased by prostaglandin E2 in rat primary astrocytes via EP2-evoked cAMP/PKA and intracellular calcium signaling. | Dinoprostone | prostaglandin E receptor 2 | Rattus norvegicus |
| 2 | Pharmacological and RNA interference approaches further indicated the involvement of the receptor EP2 in PGE(2)-induced iNOS upregulation in T/I-treated astrocytes. | Dinoprostone | prostaglandin E receptor 2 | Rattus norvegicus |
| 3 | Quantitative real-time polymerase chain reaction and gel mobility shift assays also demonstrated that PGE(2) increased iNOS transcription through EP2-induced cAMP/protein kinase A (PKA)-dependent pathway. | Dinoprostone | prostaglandin E receptor 2 | Rattus norvegicus |
| 4 | By analyzing the expression of astrocytic glial fibrillary acidic protein (GFAP), we found that PGE(2) alone only triggered the EP2-induced cAMP/PKA/p38MAPK signaling pathway in astrocytes. | Dinoprostone | prostaglandin E receptor 2 | Rattus norvegicus |