Pub. Date : 2007 Feb 1
PMID : 17086544
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we showed increased expression of serine palmitoyltransferase (SPT), the first enzyme in the ceramide biosynthetic pathway, in reactive astrocytes of the hippocampus after kainate injections. | Ceramides | alanine--glyoxylate and serine--pyruvate aminotransferase | Rattus norvegicus |
| 2 | In this study, we showed increased expression of serine palmitoyltransferase (SPT), the first enzyme in the ceramide biosynthetic pathway, in reactive astrocytes of the hippocampus after kainate injections. | Ceramides | alanine--glyoxylate and serine--pyruvate aminotransferase | Rattus norvegicus |
| 3 | In vitro studies showed that treatment of hippocampal slice cultures with SPT inhibitor ISP-1 (myriocin) or L-cycloserine modulated increases in 16:0, 18:0, and 20:0 ceramide species, and partially reduced kainate-induced cell death. | Ceramides | alanine--glyoxylate and serine--pyruvate aminotransferase | Rattus norvegicus |
| 4 | The above findings indicate a role of SPT in ceramide increase after kainate injury, although additional effects of sphingomyelinase cannot be ruled out. | Ceramides | alanine--glyoxylate and serine--pyruvate aminotransferase | Rattus norvegicus |