Title : Induction of human P-glycoprotein in Caco-2 cells: development of a highly sensitive assay system for P-glycoprotein-mediated drug transport.

Pub. Date : 2006 Oct

PMID : 17072095






5 Functional Relationships(s)
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1 To induce P-gp in Caco-2 cells, cells were cultured in vinblastine-containing medium. Vinblastine phosphoglycolate phosphatase Homo sapiens
2 The mRNA level of P-gp was approximately 7-fold higher in Caco-2 cells cultured with vinblastine (P-gp-induced Caco-2 cells) than in control cells. Vinblastine phosphoglycolate phosphatase Homo sapiens
3 The mRNA level of P-gp was approximately 7-fold higher in Caco-2 cells cultured with vinblastine (P-gp-induced Caco-2 cells) than in control cells. Vinblastine phosphoglycolate phosphatase Homo sapiens
4 Moreover, we found that P-gp expression in Caco-2 cells could be further enhanced by applying the higher concentration of vinblastine. Vinblastine phosphoglycolate phosphatase Homo sapiens
5 Transport activity of P-gp in Caco-2 cells cultured with higher concentration of vinblastine was markedly higher than that in P-gp-induced Caco-2 cells and was comparable with that in MDR1-MDCKII cells. Vinblastine phosphoglycolate phosphatase Homo sapiens