Pub. Date : 1991 Mar
PMID : 1707153
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Decrease of c-erbB-2 and c-myc RNA levels in tamoxifen-treated breast cancer. | Tamoxifen | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 2 | c-myc and c-erbB-2 expression was high in the control population (mean values: 23.4 and 29.1 grains/cell respectively) and significantly decreased in the tamoxifen-treated population (mean values: 14.6 and 7.4 grains/cell respectively) (P = 0.018, P = 0.003 respectively); hst and int-2 RNA levels were low (2-6 grains/cell) and not significantly altered by the treatment. | Tamoxifen | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 3 | In the ER+ population, the tamoxifen-treated group had significantly lower c-myc expression levels than the control group (P = 0.04) which is in agreement with the estrogen induction of c-myc in ER+ T47D cell line and its inhibition by antiestrogens. | Tamoxifen | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 4 | In the ER+ population, the tamoxifen-treated group had significantly lower c-myc expression levels than the control group (P = 0.04) which is in agreement with the estrogen induction of c-myc in ER+ T47D cell line and its inhibition by antiestrogens. | Tamoxifen | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 5 | These results suggest that in vivo tamoxifen decreases c-myc and c-erbB-2 RNA levels in breast cancer cells via two different mechanisms. | Tamoxifen | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |