Pub. Date : 2006 Dec 8
PMID : 17056014
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | KAP1 reduction markedly enhanced the induction of p21, a product of the p53 target gene, after treatment with actinomycin D or gamma-irradiation, but not with camptothecin. | Dactinomycin | tumor protein p53 | Homo sapiens |
| 2 | Treatment with actinomycin D, but not with camptothecin, augmented the interaction of p53 with Mdm2 and KAP1. | Dactinomycin | tumor protein p53 | Homo sapiens |
| 3 | Thus, the reduction of KAP1 levels promotes p53-dependent p21 induction and inhibits cell proliferation in actinomycin D-treated cells. | Dactinomycin | tumor protein p53 | Homo sapiens |