Pub. Date : 2006 Nov
PMID : 17052214
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The lipid second messenger diacylglycerol as a negative regulator of Rac signalling. | Diglycerides | Rac family small GTPase 1 | Homo sapiens |
| 2 | In addition to its well-known function as a protein kinase C activator, DAG produced by stimulation of the epidermal growth factor receptor causes the redistribution of the Rac-GAP (GTPase-activating protein) beta2-chimaerin to the plasma membrane, where it associates with the active form of Rac1 and promotes the inactivation of this small G-protein. | Diglycerides | Rac family small GTPase 1 | Homo sapiens |
| 3 | This represents the first example of a Rac-GAP regulated directly by DAG in response to the activation of a tyrosine kinase receptor, and suggests a previously unappreciated role for this lipid as a negative modulator of Rac signalling. | Diglycerides | Rac family small GTPase 1 | Homo sapiens |