Title : Cytotoxic activity of gemtuzumab ozogamicin (Mylotarg) in acute myeloid leukemia correlates with the expression of protein kinase Syk.

Pub. Date : 2006 Dec

PMID : 17051243






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Syk upregulation by the de-methylating agent 5-azacytidine (5-aza) induced re-expression of Syk in some cases, resulting in enhanced GO and anti-CD33-mediated inhibition of leukemia cell growth. Azacitidine CD33 molecule Homo sapiens
2 Syk upregulation by the de-methylating agent 5-azacytidine (5-aza) induced re-expression of Syk in some cases, resulting in enhanced GO and anti-CD33-mediated inhibition of leukemia cell growth. Azacitidine CD33 molecule Homo sapiens
3 5-Aza restored Syk and increased the sensitivity of originally Syk-negative, non-responsive cells to CD33 ligation to levels of Syk-positive cells. Azacitidine CD33 molecule Homo sapiens