Pub. Date : 2006 Nov
PMID : 17047487
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Influence of CYP2D6 polymorphism on 3,4-methylenedioxymethamphetamine ("Ecstasy") cytotoxicity. | N-Methyl-3,4-methylenedioxyamphetamine | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |
| 2 | Therefore, we tested whether CYP2D6 or its variant alleles as well as CYP3A4 influence the susceptibility to 3,4-methylenedioxymethamphetamine. | N-Methyl-3,4-methylenedioxyamphetamine | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |
| 3 | METHODS: 3,4-Methylenedioxymethamphetamine cytotoxicity was determined in V79 cells expressing human wild-type CYP2D6 (CYP2D6*1), the low-activity alleles CYP2D6*2, *9, *10, and *17, as well as human CYP3A4. | N-Methyl-3,4-methylenedioxyamphetamine | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |
| 4 | METHODS: 3,4-Methylenedioxymethamphetamine cytotoxicity was determined in V79 cells expressing human wild-type CYP2D6 (CYP2D6*1), the low-activity alleles CYP2D6*2, *9, *10, and *17, as well as human CYP3A4. | N-Methyl-3,4-methylenedioxyamphetamine | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |
| 5 | METHODS: 3,4-Methylenedioxymethamphetamine cytotoxicity was determined in V79 cells expressing human wild-type CYP2D6 (CYP2D6*1), the low-activity alleles CYP2D6*2, *9, *10, and *17, as well as human CYP3A4. | N-Methyl-3,4-methylenedioxyamphetamine | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |
| 6 | RESULTS: Toxicity of 3,4-methylenedioxymethamphetamine was clearly increased in cells expressing CYP2D6*1 compared with the parental cells devoid of CYP-dependent enzymatic activity. | N-Methyl-3,4-methylenedioxyamphetamine | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |
| 7 | Formation of the oxidative 3,4-methylenedioxymethamphetamine metabolite N-methyl-alpha-methyldopamine was greatly enhanced in V79 cell line transfected with CYP2D6*1 compared to all other cell lines. | N-Methyl-3,4-methylenedioxyamphetamine | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |
| 8 | CONCLUSIONS: CYP2D6*1 mediates 3,4-methylenedioxymethamphetamine toxicity via formation of N-methyl-alpha-methyldopamine. | N-Methyl-3,4-methylenedioxyamphetamine | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |
| 9 | Therefore, it will be important to investigate whether CYP2D6 ultrarapid metabolizers are overrepresented in the cases of 3,4-methylenedioxymethamphetamine intoxications. | N-Methyl-3,4-methylenedioxyamphetamine | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |