Title : Noradrenergic pain modulation.

Pub. Date : 2006 Oct

PMID : 17030082






1 Functional Relationships(s)
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1 In the spinal cord, norepinephrine released from descending pathways suppresses pain by inhibitory action on alpha-2A-adrenoceptors on central terminals of primary afferent nociceptors (presynaptic inhibition), by direct alpha-2-adrenergic action on pain-relay neurons (postsynaptic inhibition), and by alpha-1-adrenoceptor-mediated activation of inhibitory interneurons. Norepinephrine adrenoceptor alpha 1D Homo sapiens