Pub. Date : 2006 Nov 1
PMID : 17029827
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The response of phosphorylated p53 may be more sensitive towards benzo[a]pyrene exposure than normal p53. | Benzo(a)pyrene | tumor protein p53 | Homo sapiens |
| 2 | Following DNA damage, the activation of p53 acts as a transcriptional regulator of several target genes, including, p21 protein; a gene that encodes the Cdk inhibitor and is induced by exposure to benzo[a]pyrene. | Benzo(a)pyrene | tumor protein p53 | Homo sapiens |
| 3 | The p53 mRNA level was increased after the treatment of cells with benzo[a]pyrene, as well as following the induction of p53 protein, suggesting the benzo[a]pyrene-stimulated p53 accumulation may also be transcriptionally induced. | Benzo(a)pyrene | tumor protein p53 | Homo sapiens |
| 4 | The p53 mRNA level was increased after the treatment of cells with benzo[a]pyrene, as well as following the induction of p53 protein, suggesting the benzo[a]pyrene-stimulated p53 accumulation may also be transcriptionally induced. | Benzo(a)pyrene | tumor protein p53 | Homo sapiens |
| 5 | The p53 mRNA level was increased after the treatment of cells with benzo[a]pyrene, as well as following the induction of p53 protein, suggesting the benzo[a]pyrene-stimulated p53 accumulation may also be transcriptionally induced. | Benzo(a)pyrene | tumor protein p53 | Homo sapiens |
| 6 | The p53 mRNA level was increased after the treatment of cells with benzo[a]pyrene, as well as following the induction of p53 protein, suggesting the benzo[a]pyrene-stimulated p53 accumulation may also be transcriptionally induced. | Benzo(a)pyrene | tumor protein p53 | Homo sapiens |
| 7 | The overall results suggest that benzo[a]pyrene leads to serious DNA damage, which leads to the transcription of the p53 gene; that the subsequent p53 protein accumulation up-regulates the cellular p21 protein. | Benzo(a)pyrene | tumor protein p53 | Homo sapiens |
| 8 | The overall results suggest that benzo[a]pyrene leads to serious DNA damage, which leads to the transcription of the p53 gene; that the subsequent p53 protein accumulation up-regulates the cellular p21 protein. | Benzo(a)pyrene | tumor protein p53 | Homo sapiens |
| 9 | Oxidative DNA damage and p53 accumulation seem to be related to benzo[a]pyrene toxicity; however, their potential as biomarkers in environmental monitoring and risk assessment needs to be validated in the context of their specificity and sensitivity. | Benzo(a)pyrene | tumor protein p53 | Homo sapiens |