Title : A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization.

Pub. Date : 2006 Oct 1

PMID : 17015431






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Nocodazole, a microtubule poison that provokes centrosome/mitotic apparatus dysfunction, induces Lats2 translocation from centrosomes to the nucleus and p53 accumulation. Nocodazole tumor protein p53 Homo sapiens
2 Abrogation of Lats2 promotes accumulation of polyploid cells upon exposure to nocodazole, which can be prevented by direct activation of p53. Nocodazole tumor protein p53 Homo sapiens