Pub. Date : 2007
PMID : 17000130
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Regulation of acetylcholinesterase expression by calcium signaling during calcium ionophore A23187- and thapsigargin-induced apoptosis. | Calcimycin | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 2 | During apoptosis, treatment of HeLa and MDA-MB-435s cells with the calcium ionophore A23187 resulted in a significant increase in acetylcholinesterase mRNA and protein levels. | Calcimycin | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 3 | A23187 also enhanced the stability of acetylcholinesterase mRNA and increased the activity of acetylcholinesterase promoter, effects that were blocked by BAPTA-AM. | Calcimycin | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 4 | A23187 also enhanced the stability of acetylcholinesterase mRNA and increased the activity of acetylcholinesterase promoter, effects that were blocked by BAPTA-AM. | Calcimycin | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 5 | We further demonstrated that the transactivation of the human acetylcholinesterase promoter by A23187 and thapsigargin was partially mediated by a CCAAT motif within the -1270 to -1248 fragment of the human acetylcholinesterase promoter. | Calcimycin | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 6 | We further demonstrated that the transactivation of the human acetylcholinesterase promoter by A23187 and thapsigargin was partially mediated by a CCAAT motif within the -1270 to -1248 fragment of the human acetylcholinesterase promoter. | Calcimycin | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 7 | These results strongly suggest that cytosolic Ca(2+) plays a key role in acetylcholinesterase regulation during apoptosis induced by A23187 and thapsigargin. | Calcimycin | acetylcholinesterase (Cartwright blood group) | Homo sapiens |