Title : Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus.

Pub. Date : 2006 Oct 30

PMID : 16996037






1 Functional Relationships(s)
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1 Here, we found that a single application of Semax (50 microg/kg body weight) results in a maximal 1.4-fold increase of BDNF protein levels accompanying with 1.6-fold increase of trkB tyrosine phosporylation levels, and a 3-fold and a 2-fold increase of exon III BDNF and trkB mRNA levels, respectively, in the rat hippocampus. Tyrosine neurotrophic receptor tyrosine kinase 2 Rattus norvegicus