Title : X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation.

Pub. Date : 2006 Dec 8

PMID : 16990259






2 Functional Relationships(s)
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Protein Name
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1 The observed agonist-bound state contains the ERRgamma LBD, a ligand (GSK4716), and the RIP140 peptide and reveals an unexpected rearrangement of the phenol-binding residues. GSK 4716 estrogen related receptor gamma Homo sapiens
2 In contrast to the conventional mechanism of nuclear receptor ligand activation, activation of ERRgamma by GSK4716 does not appear to involve a major rearrangement or significant stabilization of the C-terminal helix. GSK 4716 estrogen related receptor gamma Homo sapiens