Title : Inhibition of NF-kappa B activation through targeting I kappa B kinase by celastrol, a quinone methide triterpenoid.

Pub. Date : 2006 Nov 15

PMID : 16984800






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Preincubation of celastrol completely blocked the LPS-, TNF-alpha-, or PMA-induced degradation and phosphorylation of I kappa B alpha. celastrol tumor necrosis factor Homo sapiens
2 Celastrol prevented not only LPS-induced mRNA expression of iNOS and TNF-alpha, but also TNF-alpha-induced Bfl-1/A1 expression, a prosurvival Bcl-2 homologue. celastrol tumor necrosis factor Homo sapiens
3 Celastrol prevented not only LPS-induced mRNA expression of iNOS and TNF-alpha, but also TNF-alpha-induced Bfl-1/A1 expression, a prosurvival Bcl-2 homologue. celastrol tumor necrosis factor Homo sapiens