Title : NO modulates NADPH oxidase function via heme oxygenase-1 in human endothelial cells.

Pub. Date : 2006 Nov

PMID : 16982957






1 Functional Relationships(s)
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1 DETA-NONOate alone had little effect on TNF-stimulated reactive oxygen species, but it enhanced the TNF response when: (1) heme oxygenase-1 expression was blocked with specific small-interfering RNA; (2) heme oxygenase-1 activity was blocked by zinc-protoporphyrin; or (3) NADPH oxidase activity was blocked by diphenyleneiodonium. 2,2'-(hydroxynitrosohydrazono)bis-ethanamine tumor necrosis factor Homo sapiens