Title : DNA modification with cisplatin affects sequence-specific DNA binding of p53 and p73 proteins in a target site-dependent manner.

Pub. Date : 2006 Oct

PMID : 16981908






2 Functional Relationships(s)
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1 DNA modification with cisplatin affects sequence-specific DNA binding of p53 and p73 proteins in a target site-dependent manner. Cisplatin tumor protein p73 Homo sapiens
2 Here we demonstrate that the effects of global DNA modification with cisplatin on binding of the p53 or p73 proteins to various p53 DNA-binding sites differed significantly, depending on the nucleotide sequence of the given target site. Cisplatin tumor protein p73 Homo sapiens