Pub. Date : 2007 Feb
PMID : 16977328
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Membrane-localized activation of glucuronide prodrugs by beta-glucuronidase enzymes. | Glucuronides | glucuronidase, beta | Mus musculus |
| 2 | In this study, we expressed human, murine and Esherichia coli beta-glucuronidase on tumor cells and examined their in vitro and in vivo efficacy for the activation of glucuronide prodrugs of 9-aminocamptothecin and p-hydroxy aniline mustard. | Glucuronides | glucuronidase, beta | Mus musculus |
| 3 | Our results demonstrate that surface expression of murine beta-glucuronidase for activation of a glucuronide prodrug of p-hydroxy aniline mustard may be useful for more selective therapy of cancer. | Glucuronides | glucuronidase, beta | Mus musculus |