Title : Modulation of contractile function through neuropeptide Y receptors during development of cardiomyocyte hypertrophy.

Pub. Date : 2006 Dec

PMID : 16973886






2 Functional Relationships(s)
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1 BIBP3226 unmasked a negative contraction effect of NPY, elicited over the concentration range (10(-12) to 3 x 10(-9) M) in which NPY and PYY(3-36) attenuated the positive contraction effects of isoproterenol, the potencies of which were increased in cardiomyocytes from SHRs at 20 weeks (175- and 145-fold versus controls); maximal responses were not altered. Isoproterenol neuropeptide Y Rattus norvegicus
2 BIBP3226 unmasked a negative contraction effect of NPY, elicited over the concentration range (10(-12) to 3 x 10(-9) M) in which NPY and PYY(3-36) attenuated the positive contraction effects of isoproterenol, the potencies of which were increased in cardiomyocytes from SHRs at 20 weeks (175- and 145-fold versus controls); maximal responses were not altered. Isoproterenol neuropeptide Y Rattus norvegicus