Title : Simvastatin inhibits the migration and adhesion of monocytic cells and disorganizes the cytoskeleton of activated endothelial cells.

Pub. Date : 2006 Oct 24

PMID : 16973154






2 Functional Relationships(s)
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1 Simvastatin also significantly reduced the adhesion of monocytes to interleukin-1beta (IL-1beta)-activated endothelium to 80% after preincubation for 24 h. This effect was completely reversed by coincubation with MVA and GGPP, and partially with FPP. farnesyl pyrophosphate interleukin 1 beta Homo sapiens
2 Simvastatin also significantly reduced the adhesion of monocytes to interleukin-1beta (IL-1beta)-activated endothelium to 80% after preincubation for 24 h. This effect was completely reversed by coincubation with MVA and GGPP, and partially with FPP. farnesyl pyrophosphate interleukin 1 beta Homo sapiens