Title : La(3+)-induced extracellular signal-regulated kinase (ERK) signaling via a metal-sensing mechanism linking proliferation and apoptosis in NIH 3T3 cells.

Pub. Date : 2006 Sep 19

PMID : 16964983






5 Functional Relationships(s)
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Protein Name
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1 La(3+)-induced extracellular signal-regulated kinase (ERK) signaling via a metal-sensing mechanism linking proliferation and apoptosis in NIH 3T3 cells. lanthanum(3+) mitogen-activated protein kinase 1 Mus musculus
2 La(3+)-induced extracellular signal-regulated kinase (ERK) signaling via a metal-sensing mechanism linking proliferation and apoptosis in NIH 3T3 cells. lanthanum(3+) mitogen-activated protein kinase 1 Mus musculus
3 The effects of La(3+) on the extracellular signal-regulated kinase (ERK) signaling were investigated to explore the mechanism by which La(3+) results in cell proliferation associated with apoptosis in mouse embryo fibroblast NIH 3T3 cells. lanthanum(3+) mitogen-activated protein kinase 1 Mus musculus
4 Our data showed that La(3+) ions could induce a pulse of phosphorylation of ERK mainly through an unknown metal-sensing mechanism, which is different from the Ca(2+)-sensing receptor . lanthanum(3+) mitogen-activated protein kinase 1 Mus musculus
5 Therefore, the experimental results suggested that La(3+) induced cell proliferation and apoptosis compatible to a p53-related mechanism in NIH 3T3 cells via an ERK-signaling cascade induced by a metal-sensing mechanism. lanthanum(3+) mitogen-activated protein kinase 1 Mus musculus