Title : Mitochondrial PKC epsilon and mitochondrial ATP-sensitive K+ channel copurify and coreconstitute to form a functioning signaling module in proteoliposomes.

Pub. Date : 2006 Oct 13

PMID : 16960097






5 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Recently, protein kinase C epsilon (PKC epsilon) has been identified as a component of the mitoK(ATP) signaling cascade. Adenosine Triphosphate protein kinase C epsilon Homo sapiens
2 Recently, protein kinase C epsilon (PKC epsilon) has been identified as a component of the mitoK(ATP) signaling cascade. Adenosine Triphosphate protein kinase C epsilon Homo sapiens
3 Addition of the PKC activators 12-phorbol 13-myristate acetate, hydrogen peroxide, and the specific PKC epsilon peptide agonist, psi epsilonRACK, each activated mitoK(ATP)-dependent K+ flux in the reconstituted system. Adenosine Triphosphate protein kinase C epsilon Homo sapiens
4 Addition of the PKC activators 12-phorbol 13-myristate acetate, hydrogen peroxide, and the specific PKC epsilon peptide agonist, psi epsilonRACK, each activated mitoK(ATP)-dependent K+ flux in the reconstituted system. Adenosine Triphosphate protein kinase C epsilon Homo sapiens
5 This effect of PKC epsilon was prevented by chelerythrine, by the specific PKC epsilon peptide antagonist, epsilonV(1-2), and by the specific mitoK(ATP) inhibitor 5-hydroxydecanoate. Adenosine Triphosphate protein kinase C epsilon Homo sapiens