Pub. Date : 2006 Dec
PMID : 16956955
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Identification of binding sites of non-I-helix water molecules in mammalian cytochromes p450. | Water | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 2 | The study of P450-bound waters has been largely restricted to bacterial enzymes that may or may not reflect the location or function of waters in human drug-metabolizing P450s. | Water | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 3 | The study of P450-bound waters has been largely restricted to bacterial enzymes that may or may not reflect the location or function of waters in human drug-metabolizing P450s. | Water | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 4 | Described herein is the identification of seven well defined water clusters in mammalian P450s identified by calculating the density of globally aligned waters as reported by Tanner and coworkers [Bottoms CA, White TA, and Tanner JJ (2006) Proteins 64:404-421 (DOI: 10.1002/prot.21014)]. | Water | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 5 | All water binding sites were in or within the immediate vicinity of the active sites of the P450s, but most were not near the conserved I-helix threonine often implicated in P450 catalysis. | Water | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 6 | All water binding sites were in or within the immediate vicinity of the active sites of the P450s, but most were not near the conserved I-helix threonine often implicated in P450 catalysis. | Water | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 7 | Therefore, it is possible that some of the water binding sites identified here ultimately determine P450 catalytic efficiency either by working as an extension of the I-helix water network, or by acting in novel proton shuttles that modulate the nonproductive shunting of reactive oxygen species. | Water | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 8 | Therefore, it is possible that some of the water binding sites identified here ultimately determine P450 catalytic efficiency either by working as an extension of the I-helix water network, or by acting in novel proton shuttles that modulate the nonproductive shunting of reactive oxygen species. | Water | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |