Title : DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis.

Pub. Date : 2006 Aug 28

PMID : 16943182






1 Functional Relationships(s)
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1 In DOCK2-deficient neutrophils, chemoattractant-induced activation of both Rac1 and Rac2 were severely impaired, resulting in the loss of polarized accumulation of F-actin and phosphatidylinositol 3,4,5-triphosphate (PIP3) at the leading edge. PIP3 Rac family small GTPase 1 Homo sapiens