Title : TNFalpha-induced cytoprotection requires the production of free radicals within mitochondria in C2C12 myotubes.

Pub. Date : 2006 Nov 2

PMID : 16938314






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The ROS scavenger, N-2-mercaptopropionyl-glycine (MPG), reduced the viability of TNFalpha-stimulated cells to 15 +/- 1% (p<0.001 versus TNFalpha). Reactive Oxygen Species N-methylpurine DNA glycosylase Homo sapiens
2 The ROS scavenger, N-2-mercaptopropionyl-glycine (MPG), reduced the viability of TNFalpha-stimulated cells to 15 +/- 1% (p<0.001 versus TNFalpha). Reactive Oxygen Species N-methylpurine DNA glycosylase Homo sapiens
3 TNFalpha stimulation increased ROS production mainly in the mitochondria, and this increase was abolished in the presence of MPG. Reactive Oxygen Species N-methylpurine DNA glycosylase Homo sapiens