Pub. Date : 2006 Nov
PMID : 16928788
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In liver, PCN induced the expression of Oatp1a4 and Mrp3 mRNA in wild-type (WT) mouse liver, but not in PXR-null mice. | Pregnenolone Carbonitrile | prolactin family 2, subfamily c, member 4 | Mus musculus |
| 2 | Therefore, PCN regulates the expression of some transporters, namely, Oatp1a4 and Mrp3 in liver, as well as Abca1, Cnt2, Mdr1a, and Mrp2 in small intestine via a PXR-mediated mechanism. | Pregnenolone Carbonitrile | prolactin family 2, subfamily c, member 4 | Mus musculus |