Title : Cell-type specific and differential regulation of the human metallothionein genes. Correlation with DNA methylation and chromatin structure.

Pub. Date : 1990 Apr 15

PMID : 1690731






2 Functional Relationships(s)
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Protein Name
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1 The MT-IF or MT-IG and the MT-IIA genes were regulated in a cell-type specific manner in response to heavy metals and dexamethasone, respectively. Dexamethasone metallothionein 1G Homo sapiens
2 DNA methylation was shown to be correlated to cell-type specific regulation of MT gene expression since 5-azacytidine treatment resulted in the expression of the MT-IF and MT-IG genes in response to cadmium and zinc in Wi-L2 cells, of the MT-IIA gene in response to dexamethasone in Wi-L2 cells, and of the MT-IG in response to zinc and copper in Hek 293 cells. Dexamethasone metallothionein 1G Homo sapiens