Title : Molecular determinants of irinotecan efficacy.

Pub. Date : 2006 Nov 15

PMID : 16894565






2 Functional Relationships(s)
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Protein Name
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1 High intratumoral mRNA levels of EGFR, ERCC1 and GSPT-P1 were each significantly associated with response to CPT-11 based chemotherapy. Irinotecan ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens
2 This small retrospective study suggests that gene expression levels of EGFR, ERCC1 and GST-P1 may be useful in predicting the clinical outcome of patients with metastatic CRC treated with first-line CPT-11 based chemotherapy. Irinotecan ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens