Title : Inhibition of the TPA-induced cutaneous inflammation and hyperplasia by EC-SOD.

Pub. Date : 2006 Sep 22

PMID : 16890203






4 Functional Relationships(s)
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1 The expressions of the inflammatory cytokines, IL-1alpha and IL-1beta, were reduced in the TPA-treated Tg EC-SOD compared with those in TPA-treated WT. Tetradecanoylphorbol Acetate interleukin 1 beta Mus musculus
2 The expressions of the inflammatory cytokines, IL-1alpha and IL-1beta, were reduced in the TPA-treated Tg EC-SOD compared with those in TPA-treated WT. Tetradecanoylphorbol Acetate interleukin 1 beta Mus musculus
3 The number of infiltrating inflammatory cells and the IL-1beta expressing cells was obviously reduced in TPA-treated Tg EC-SOD in comparison with TPA-treated WT. Tetradecanoylphorbol Acetate interleukin 1 beta Mus musculus
4 The result suggests that EC-SOD might play an important role in the suppression of TPA-induced cutaneous inflammation and epidermal hyperplasia by regulating the expression of IL-1alpha and IL-1beta, although the mechanisms remain to be elucidated. Tetradecanoylphorbol Acetate interleukin 1 beta Mus musculus