Pub. Date : 2006 Oct 1
PMID : 16889744
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Although its physiological ligand is unknown, ERRgamma has been shown to interact with synthetic estrogenic compounds such as 4-hydroxytamoxifen (4-OHT), tamoxifen, and diethylstilbestrol (DES). | 4,17 beta-dihydroxy-4-androstene-3-one | estrogen related receptor gamma | Homo sapiens |
| 2 | Fluorescein-labeled PGC1alpha peptide was displaced from the ERRgamma LBD in the presence of increasing concentrations of 4-OHT and tamoxifen, but DES was less effective in PGC1alpha displacement. | 4,17 beta-dihydroxy-4-androstene-3-one | estrogen related receptor gamma | Homo sapiens |
| 3 | These findings also suggest that binding of 4-OHT, tamoxifen, or DES to ERRgamma results in differential affinity of coregulators for ERRgamma due to unique ligand-induced conformations. | 4,17 beta-dihydroxy-4-androstene-3-one | estrogen related receptor gamma | Homo sapiens |
| 4 | These findings also suggest that binding of 4-OHT, tamoxifen, or DES to ERRgamma results in differential affinity of coregulators for ERRgamma due to unique ligand-induced conformations. | 4,17 beta-dihydroxy-4-androstene-3-one | estrogen related receptor gamma | Homo sapiens |