Title : The role of intracellular zinc in chromium(VI)-induced oxidative stress, DNA damage and apoptosis.

Pub. Date : 2006 Sep 25

PMID : 16887109






2 Functional Relationships(s)
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1 Cr(VI) (50, 10 and 1 microM) was found to produce time- and dose-dependent cytotoxicity resulting in oxidative stress, suppression of antioxidant systems and activation of p53-dependent apoptosis which is reported for the first time in this model in relation to environmental Cr(VI). Chromium tumor protein p53 Homo sapiens
2 Cr(VI) (50, 10 and 1 microM) was found to produce time- and dose-dependent cytotoxicity resulting in oxidative stress, suppression of antioxidant systems and activation of p53-dependent apoptosis which is reported for the first time in this model in relation to environmental Cr(VI). Chromium tumor protein p53 Homo sapiens