Title : Allosteric activation of antithrombin is independent of charge neutralization or reversal in the heparin binding site.

Pub. Date : 2006 Aug 21

PMID : 16884719






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We investigate the hypothesis that heparin activates antithrombin (AT) by relieving electrostatic strain within helix D. Mutation of residues K125 and R129 to either Ala or Glu abrogated heparin binding, but did not activate AT towards inhibition of factors IXa or Xa. Alanine serpin family C member 1 Homo sapiens