Title : Synthesis of substituted phenyl diaziridines and characterization as mechanism-based inactivators of human cytochrome P450 2B6.

Pub. Date : 2006 Nov

PMID : 16882766






1 Functional Relationships(s)
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1 Interestingly, a thiomethyl-substituted phenyl diaziridine had no effect on the activity of P450 2B6 in the reconstituted system, but competitively inhibited the O-debenzylation activity of P450 3A4 with 7-benzyloxy-4-(trifluoromethyl)coumarin as substrate. 7-benzyloxy-4-trifluoromethylcoumarin cytochrome P450 family 2 subfamily B member 6 Homo sapiens