Title : Mode of action of beta-cyclodextrin as an absorption enhancer of the water-soluble drug meglumine antimoniate.

Pub. Date : 2006 Nov 15

PMID : 16876345






4 Functional Relationships(s)
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1 It has been previously reported that beta-cyclodextrin (beta-CD) enhances the oral absorption of the pentavalent antimony (Sb) drug, meglumine antimoniate (MA). Antimony beta-carotene oxygenase 1 Mus musculus
2 When MA solution was heated for 48 h at 55 degrees C to mimic the conditions used to prepare MA/beta-CD, MA was found to suffer dissociation, from high molecular weight Sb complexes into species of lower molecular weight. Antimony beta-carotene oxygenase 1 Mus musculus
3 In vitro skin permeation experiments using MA and MA/beta-CD indicated a two-fold increase in the Sb flux for MA/beta-CD. Antimony beta-carotene oxygenase 1 Mus musculus
4 In vitro skin permeation experiments using MA and MA/beta-CD indicated a two-fold increase in the Sb flux for MA/beta-CD. Antimony beta-carotene oxygenase 1 Mus musculus