Title : Metallopeptide-promoted inactivation of angiotensin-converting enzyme and endothelin-converting enzyme 1: Toward dual-action therapeutics.

Pub. Date : 2006 Oct

PMID : 16874470






1 Functional Relationships(s)
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1 Moreover, the inhibition observed for [KGHK-Co(NH3)2]2+ contrasts with the activation of hACE by Co2+(aq), reflecting the stimulation of enzyme activity following replacement of the catalytic zinc cofactor by cobalt ion at each of the two active sites. Cobalt angiotensin I converting enzyme Homo sapiens