Pub. Date : 2006 Aug
PMID : 16872559
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effect of leptin administration on membrane-bound adenosine triphosphatase activity in ethanol-induced experimental liver toxicity. | Ethanol | leptin | Mus musculus |
| 2 | We have explored the effect of leptin on hepatic marker enzyme and membrane-bound adenosine triphosphatases in ethanol-induced liver toxicity in mice. | Ethanol | leptin | Mus musculus |
| 3 | Ethanol feeding to mice significantly (P < 0.05) elevated the plasma leptin, alanine transaminase (ALT), alkaline phosphatase (ALP), gamma-glutamyl transpeptidase (GGT) and hepatic lipid hydroperoxides (LOOH), and plasma and hepatic total ATPases, Na(+), K(+)-ATPase and Mg(2+)-ATPase. | Ethanol | leptin | Mus musculus |
| 4 | Leptin injections to ethanol-fed animals further elevated the levels of hepatic LOOH, plasma and hepatic total ATPases, Na(+), K(+)-ATPase and Mg(2+)-ATPase, while the Ca(2)-ATPase and GSH were decreased significantly. | Ethanol | leptin | Mus musculus |
| 5 | In addition, leptin administration was found to increase the plasma levels of leptin, ALT, ALP, GGT, Na(+) and inorganic phosphorous, and decrease the levels of K(+) and Ca(2+) in ethanol-fed mice. | Ethanol | leptin | Mus musculus |
| 6 | These findings were consistent with our histological observations, confirming that leptin enhanced liver ailments in ethanol-supplemented mice. | Ethanol | leptin | Mus musculus |