Pub. Date : 2006 Oct 15
PMID : 16870173
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ni(II) affects ubiquitination of core histones H2B and H2A. | Nickel(2+) | H2B clustered histone 21 | Homo sapiens |
| 2 | Previously, we found that exposure of cells to Ni(II) resulted in truncation of histones H2A and H2B and thus elimination of some modification sites. | Nickel(2+) | H2B clustered histone 21 | Homo sapiens |
| 3 | Here, we investigated the effect of Ni(II) on one such modification, ubiquitination, of histones H2B and H2A in nuclei of cultured 1HAEo- and HPL1D human lung cells. | Nickel(2+) | H2B clustered histone 21 | Homo sapiens |
| 4 | Overall, our results suggest that dysregulation of H2B ubiquitination is a part of Ni(II) adverse effects on gene expression and DNA repair which may assist in cell transformation. | Nickel(2+) | H2B clustered histone 21 | Homo sapiens |