Title : Role for enhanced faecal excretion of bile acid in hydroxysteroid sulfotransferase-mediated protection against lithocholic acid-induced liver toxicity.

Pub. Date : 2006 Jul

PMID : 16864508






1 Functional Relationships(s)
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1 Whereas induction of Cyp3a and hydroxysteroid sulfotransferase (Sult2a) proteins was observed in FXR-null and wild-type mice, clear increases in biliary 3alpha-sulfated TLCA but not total 6alpha-hydroxy LCA (taurohyodeoxycholic acid and hyodeoxycholic acid) were only observed in PCN-treated wild-type mice. taurohyodeoxycholic acid cytochrome P450, family 3, subfamily a, polypeptide 11 Mus musculus