Title : Inhibition of colon cancer (HT-29) cell proliferation by a triterpenoid isolated from Azadirachta indica is accompanied by cell cycle arrest and up-regulation of p21.

Pub. Date : 2006 Aug

PMID : 16858664






1 Functional Relationships(s)
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1 Western blot analysis revealed that nimbolide-mediated G2/M arrest was accompanied by the up-regulation of p21, cyclin D2, Chk2; and down-regulation of cyclin A, cyclin E, Cdk2, Rad17. nimbolide RAD17 checkpoint clamp loader component Homo sapiens