Title : Early cytotoxic effects of ochratoxin A in rat liver: a morphological, biochemical and molecular study.

Pub. Date : 2006 Aug 15

PMID : 16857307






1 Functional Relationships(s)
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1 We characterized the overall early effect of chronic ochratoxin A (OTA) treatment on rat liver, analyzing different aspects related to: (i) fibrosis, by measuring collagen content and turnover, and alpha-smooth muscle actin (alphaSMA); (ii) oxidative stress and stress response, by analyzing protein carbonylation, superoxide dismutase (SOD) and heat shock protein (HSP70) gene expression; (iii) the possible tumor promoter effect, evaluating cadherin and connexin (CX) mRNA levels. ochratoxin A heat shock protein family A (Hsp70) member 1B Rattus norvegicus