Pub. Date : 2005 Dec 8
PMID : 16854005
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Whereas G121/G116, G122/G117, and A204/A199 of AChE/BChE all can form hydrogen bonds with ACh to stabilize the transition state during the ACh hydrolysis, BChE only uses G117 and A199 to form hydrogen bonds with cocaine. | Cocaine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 2 | These results help to understand why the catalytic activity of AChE against ACh is considerably higher than that of BChE against cocaine and provides valuable clues on how to improve the catalytic activity of BChE against cocaine. | Cocaine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |