Title : Altered oral bioavailability and pharmacokinetics of P-glycoprotein substrates by coadministration of biochanin A.

Pub. Date : 2006 Sep

PMID : 16850393






2 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Fexofenadine is a substrate for Pgp, Oatp1, Oatp2, and Oatp3. fexofenadine phosphoglycolate phosphatase Rattus norvegicus
2 BA appears to preferentially inhibit Oatp3 over Pgp in the intestine, leading to the decreased oral absorption of fexofenadine. fexofenadine phosphoglycolate phosphatase Rattus norvegicus